Neuroserpin

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.^[5]

SERPINI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3F02, 3F5N, 3FGQ
Identifiers
Aliases	SERPINI1, PI12, neuroserpin, serpin family I member 1, HNS-S2, HNS-S1
External IDs	OMIM: 602445; MGI: 1194506; HomoloGene: 21045; GeneCards: SERPINI1; OMA:SERPINI1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.1 Start 167,735,243 bp[1] End 167,825,569 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 75,464,854 bp[2] End 75,550,802 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole orbitofrontal cortex Brodmann area 10 middle temporal gyrus superior frontal gyrus Brodmann area 23 postcentral gyrus dorsolateral prefrontal cortex endothelial cell Brodmann area 46 Top expressed in Region I of hippocampus proper mammillary body prefrontal cortex primary motor cortex subiculum perirhinal cortex piriform cortex CA3 field ventral tegmental area dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular exosome secretory granule lumen soma cytoplasmic vesicle lumen extracellular space cytoplasmic vesicle perikaryon Biological process central nervous system development negative regulation of peptidase activity regulation of cell adhesion peripheral nervous system development negative regulation of endopeptidase activity positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5274 20713 Ensembl ENSG00000163536 ENSMUSG00000027834 UniProt Q99574 O35684 RefSeq (mRNA) NM_005025 NM_001122752 NM_009250 NM_001357514 RefSeq (protein) NP_001116224 NP_005016 NP_033276 NP_001344443 Location (UCSC) Chr 3: 167.74 – 167.83 Mb Chr 3: 75.46 – 75.55 Mb PubMed search [3] [4]
Wikidata
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It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM]^[5]

Interactions

SERPINI1 has been shown to interact with Tissue plasminogen activator.^[6]