SETD7

Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene.^[5][6][7]

SETD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H3I, 1MT6, 1MUF, 1N6A, 1N6C, 1O9S, 1XQH, 2F69, 3CBM, 3CBO, 3CBP, 3M53, 3M54, 3M55, 3M56, 3M57, 3M58, 3M59, 3M5A, 3OS5, 3VUZ, 3VV0, 4E47, 4J7F, 4J8O, 4JDS, 4JLG, 5EG2, 5AYF
Identifiers
Aliases	SETD7, KMT7, SET7, SET7/9, SET9, SET domain containing lysine methyltransferase 7, SET domain containing 7, histone lysine methyltransferase
External IDs	OMIM: 606594; MGI: 1920501; HomoloGene: 12741; GeneCards: SETD7; OMA:SETD7 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.1 Start 139,495,941 bp[1] End 139,606,699 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 51,422,740 bp[2] End 51,468,300 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle cardiac muscle tissue of right atrium myocardium of left ventricle skin of arm quadriceps femoris muscle Skeletal muscle tissue of rectus abdominis biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii Top expressed in triceps brachii muscle temporal muscle sternocleidomastoid muscle ciliary body digastric muscle lobe of cerebellum cerebellar vermis ankle lateral geniculate nucleus epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity p53 binding chromatin binding protein-lysine N-methyltransferase activity protein binding histone-lysine N-methyltransferase activity Cellular component nucleoplasm chromosome nucleolus nucleus Biological process regulation of transcription, DNA-templated peptidyl-lysine monomethylation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated peptidyl-lysine methylation methylation heterochromatin organization peptidyl-lysine dimethylation histone lysine methylation response to ethanol regulation of histone H3-K9 methylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80854 73251 Ensembl ENSG00000145391 ENSMUSG00000037111 UniProt Q8WTS6 Q8VHL1 RefSeq (mRNA) NM_001306199 NM_001306200 NM_030648 NM_080793 RefSeq (protein) NP_001293128 NP_001293129 NP_085151 NP_542983 Location (UCSC) Chr 4: 139.5 – 139.61 Mb Chr 3: 51.42 – 51.47 Mb PubMed search [3] [4]
Wikidata
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