Surfactant protein D

Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin.^[5] In humans, SP-D is encoded by the SFTPD gene^[6][7] and is part of the innate immune system.^[8][9] Each SP-D subunit is composed of an N-terminal domain, a collagenous region, a nucleating neck region, and a C-terminal lectin domain.^[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.^[5][10]

SFTPD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18
Identifiers
Aliases	SFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein D
External IDs	OMIM: 178635; MGI: 109515; HomoloGene: 2272; GeneCards: SFTPD; OMA:SFTPD - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.3 Start 79,937,467 bp[1] End 79,982,614 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 22.36 cM Start 40,894,171 bp[2] End 40,907,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung visceral pleura upper lobe of lung upper lobe of left lung right lung testicle germinal epithelium body of pancreas skin of leg left lobe of thyroid gland Top expressed in right lung right lung lobe left lung left lung lobe lacrimal gland trachea olfactory epithelium parotid gland uterus conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding carbohydrate binding identical protein binding lipopolysaccharide binding monosaccharide binding Cellular component cytoplasm collagen endoplasmic reticulum membrane clathrin-coated endocytic vesicle endocytic vesicle extracellular region lysosome extracellular space multivesicular body rough endoplasmic reticulum Biological process surfactant homeostasis positive regulation of phagocytosis immune system process receptor-mediated endocytosis respiratory gaseous exchange by respiratory system reactive oxygen species metabolic process regulation of cytokine production negative regulation of T cell proliferation macrophage chemotaxis defense response to bacterium regulation of immune response lung alveolus development innate immune response toll-like receptor signaling pathway induction of bacterial agglutination regulation of adhesion of symbiont to host epithelial cell developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6441 20390 Ensembl ENSG00000133661 ENSMUSG00000021795 UniProt P35247 P50404 RefSeq (mRNA) NM_003019 NM_009160 RefSeq (protein) NP_003010 NP_033186 Location (UCSC) Chr 10: 79.94 – 79.98 Mb Chr 14: 40.89 – 40.91 Mb PubMed search [3] [4]
Wikidata
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Interactions

Surfactant protein D has been shown to interact with DMBT1,^[11][12] and hemagglutinin of influenza A virus.^[13] Post-translational modification of SP-D i.e. S-nitrosylation switches its function.^[14][15][16]

See also

• Pulmonary surfactant
• Pulmonary surfactant protein D