Shugoshin 2

Shugoshin 2 (Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.^[5][6][7]

SGO2
Identifiers
Aliases	SGO2, TRIPIN, SGOL2, shugoshin 2
External IDs	OMIM: 612425; MGI: 1098767; HomoloGene: 51867; GeneCards: SGO2; OMA:SGO2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 200,510,008 bp[1] End 200,584,096 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 28.86 cM Start 58,035,130 bp[2] End 58,065,058 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm ventricular zone thymus testicle parietal pleura gonad ganglionic eminence buccal mucosa cell Top expressed in genital tubercle secondary oocyte zygote hand spermatocyte medial ganglionic eminence tail of embryo primary oocyte atrioventricular valve maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component chromosome cytosol chromosome, centromeric region nucleus kinetochore mitotic cohesin complex nucleoplasm nuclear body Biological process cell division chromosome segregation cell cycle meiotic sister chromatid cohesion, centromeric meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151246 68549 Ensembl ENSG00000163535 ENSMUSG00000026039 UniProt Q562F6 Q7TSY8 RefSeq (mRNA) NM_001160033 NM_001160046 NM_152524 NM_001177867 NM_199007 RefSeq (protein) NP_001153505 NP_001153518 NP_689737 NP_001171338 NP_950172 Location (UCSC) Chr 2: 200.51 – 200.58 Mb Chr 1: 58.04 – 58.07 Mb PubMed search [3] [4]
Wikidata
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Function

Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin.^[8] This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.