Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase,^{[1][2][3][4][5]} that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Identifiers
EC no.	3.1.3.86
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H₂O ${\displaystyle \rightleftharpoons }$
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P₃) to produce PtdIns(3,4)P₂.