INPPL1

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.^[5][6]

INPPL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K4P, 2KSO, 2MK2, 3NR8, 4A9C
Identifiers
Aliases	INPPL1, OPSMD, SHIP2, inositol polyphosphate phosphatase like 1
External IDs	OMIM: 600829; MGI: 1333787; HomoloGene: 1204; GeneCards: INPPL1; OMA:INPPL1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,223,701 bp[1] End 72,239,105 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,471,839 bp[2] End 101,487,436 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa stromal cell of endometrium right lobe of thyroid gland muscle layer of sigmoid colon left lobe of thyroid gland right uterine tube right ovary granulocyte left uterine tube apex of heart Top expressed in muscle of thigh digastric muscle extraocular muscle Ileal epithelium internal carotid artery ventricular zone lactiferous gland cardiac muscle tissue of left ventricle temporal muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding SH2 domain binding protein binding actin binding hydrolase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component Golgi apparatus cell projection membrane filopodium plasma membrane cytoskeleton lamellipodium cytoplasm cytosol Biological process endocytosis cellular lipid metabolic process actin filament organization immune system process inositol phosphate metabolic process endochondral ossification post-embryonic development negative regulation of gene expression response to insulin cell adhesion phosphatidylinositol dephosphorylation glucose metabolic process phosphatidylinositol biosynthetic process ruffle assembly negative regulation of cell population proliferation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3636 16332 Ensembl ENSG00000165458 ENSMUSG00000032737 UniProt O15357 Q6P549 RefSeq (mRNA) NM_001567 NM_001122739 NM_010567 RefSeq (protein) NP_001558 NP_001116211 NP_034697 Location (UCSC) Chr 11: 72.22 – 72.24 Mb Chr 7: 101.47 – 101.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.^[6]

Interactions

INPPL1 has been shown to interact with:

• BCAR1,^[7]
• FLNC,^[8]
• SHC1,^[9][10][11] and
• SORBS1.^[12]