CD84

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.^[5]

CD84
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PKD
Identifiers
Aliases	CD84, LY9B, SLAMF5, hmCD84 molecule
External IDs	OMIM: 604513; MGI: 1336885; HomoloGene: 48249; GeneCards: CD84; OMA:CD84 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,541,095 bp[1] End 160,579,516 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.54 cM Start 171,667,265 bp[2] End 171,718,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia lymph node monocyte periodontal fiber appendix trabecular bone superficial temporal artery synovial membrane visceral pleura synovial joint Top expressed in stroma of bone marrow granulocyte blood calvaria thymus tibiofemoral joint spleen body of femur mesenteric lymph nodes subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process negative regulation of granulocyte macrophage colony-stimulating factor production defense response innate immune response negative regulation of interleukin-18 production cell adhesion adaptive immune response negative regulation of mast cell degranulation regulation of store-operated calcium entry negative regulation of mast cell activation leukocyte migration homophilic cell adhesion via plasma membrane adhesion molecules immune system process autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8832 12523 Ensembl ENSG00000066294 ENSMUSG00000038147 UniProt Q9UIB8 Q18PI6 RefSeq (mRNA) NM_001184879 NM_001184881 NM_001184882 NM_003874 NM_001330742 NM_001252472 NM_001289470 NM_013489 RefSeq (protein) NP_001171808 NP_001171810 NP_001171811 NP_001317671 NP_003865 NP_001239401 NP_001276399 NP_038517 Location (UCSC) Chr 1: 160.54 – 160.58 Mb Chr 1: 171.67 – 171.72 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.^[5]

Interactions

CD84 has been shown to interact with SH2D1A.^[6][7][8][9]

See also

• Cluster of differentiation