Ileal sodium/bile acid cotransporter

Ileal sodium/bile acid cotransporter, also known as apical sodium–bile acid transporter (ASBT) and ileal bile acid transporter (IBAT), is a bile acid:sodium symporter protein that in humans is encoded by the SLC10A2 gene.^[5][6]

SLC10A2
Identifiers
Aliases	SLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2, Ileal bile acid transporter, PBAM1
External IDs	OMIM: 601295; MGI: 1201406; HomoloGene: 390; GeneCards: SLC10A2; OMA:SLC10A2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q33.1 Start 103,043,998 bp[1] End 103,066,417 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 2.16 cM Start 5,133,219 bp[2] End 5,155,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa duodenum kidney tubule testicle glomerulus metanephric glomerulus human kidney gallbladder gonad Top expressed in proximal tubule human kidney right kidney ileum Paneth cell lumbar spinal ganglion left lobe of liver lumbar subsegment of spinal cord intestinal villus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function symporter activity bile acid:sodium symporter activity Cellular component integral component of membrane microvillus plasma membrane integral component of plasma membrane apical plasma membrane membrane Biological process ion transport transmembrane transport bile acid and bile salt transport sodium ion transport response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6555 20494 Ensembl ENSG00000125255 ENSMUSG00000023073 UniProt Q12908 P70172 RefSeq (mRNA) NM_000452 NM_011388 RefSeq (protein) NP_000443 NP_035518 Location (UCSC) Chr 13: 103.04 – 103.07 Mb Chr 8: 5.13 – 5.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.^[7]

As a drug target

Several medications to inhibit IBAT are under development. They include elobixibat, under development for the treatment of constipation and irritable bowel syndrome,^[8] and volixibat, under development for the treatment of nonalcoholic steatohepatitis.^[9]

• Elobixibat
• Linerixibat
• Maralixibat
• Odevixibat
• Ritivixibat
• Volixibat

See also

• Solute carrier family