Natural resistance-associated macrophage protein 1

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.^[5][6][7]

SLC11A1
Identifiers
Aliases	SLC11A1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1
External IDs	OMIM: 600266; MGI: 1345275; HomoloGene: 73884; GeneCards: SLC11A1; OMA:SLC11A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,382,029 bp[1] End 218,396,894 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 38.54 cM Start 74,414,354 bp[2] End 74,425,221 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung granulocyte monocyte blood spleen buccal mucosa cell left uterine tube left adrenal cortex bone marrow cell Top expressed in granulocyte stroma of bone marrow spleen internal carotid artery mesenteric lymph nodes tibiofemoral joint morula ciliary body blood carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function manganese ion transmembrane transporter activity protein homodimerization activity transition metal ion transmembrane transporter activity metal ion:proton antiporter activity metal ion transmembrane transporter activity cadmium ion transmembrane transporter activity iron ion transmembrane transporter activity Cellular component integral component of membrane late endosome phagocytic vesicle membrane membrane late endosome membrane integral component of plasma membrane lysosome endosome membrane plasma membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process manganese ion transmembrane transport interleukin-3 production positive regulation of phagocytosis response to bacterium response to interferon-gamma positive regulation of cytokine production iron ion homeostasis positive regulation of interferon-gamma production wound healing ion transport cellular cadmium ion homeostasis cell redox homeostasis T cell proliferation involved in immune response vacuolar acidification respiratory burst multicellular organismal iron ion homeostasis mRNA stabilization response to lipopolysaccharide antigen processing and presentation of peptide antigen positive regulation of dendritic cell antigen processing and presentation positive regulation of gene expression iron ion transport defense response to bacterium positive regulation of T-helper 1 type immune response MHC class II biosynthetic process defense response to Gram-negative bacterium cadmium ion transmembrane transport phagocytosis manganese ion transport nitrite transport macrophage activation inflammatory response T cell cytokine production interleukin-2 production negative regulation of cytokine production activation of protein kinase activity positive regulation of transcription by RNA polymerase II cellular iron ion homeostasis defense response to protozoan antimicrobial humoral response neutrophil degranulation metal ion transport iron ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6556 18173 Ensembl ENSG00000018280 ENSMUSG00000026177 UniProt P49279 P41251 RefSeq (mRNA) NM_000578 NM_001032220 NM_013612 RefSeq (protein) NP_000569 NP_038640 Location (UCSC) Chr 2: 218.38 – 218.4 Mb Chr 1: 74.41 – 74.43 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.^[8] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.^[7]

See also

• Solute carrier family