Chloride potassium symporter 4

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.^[5]

SLC12A4
Identifiers
Aliases	SLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4
External IDs	OMIM: 604119; MGI: 1309465; HomoloGene: 21056; GeneCards: SLC12A4; OMA:SLC12A4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,943,474 bp[1] End 67,969,601 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.06 cM Start 106,670,222 bp[2] End 106,692,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ascending aorta stromal cell of endometrium body of uterus Descending thoracic aorta right coronary artery left lobe of thyroid gland left coronary artery tibial nerve tibial arteries Top expressed in choroid plexus of fourth ventricle molar Epithelium of choroid plexus lip ankle stroma of bone marrow body of femur yolk sac sciatic nerve calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function cation:chloride symporter activity symporter activity transporter activity protein kinase binding potassium:chloride symporter activity Cellular component lysosomal membrane plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process ion transport chemical synaptic transmission cell volume homeostasis potassium ion transport potassium ion transmembrane transport transmembrane transport chloride transmembrane transport chloride transport transport chloride ion homeostasis potassium ion homeostasis potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6560 20498 Ensembl ENSG00000124067 ENSMUSG00000017765 UniProt Q9UP95 Q9JIS8 RefSeq (mRNA) NM_005072 NM_001145961 NM_001145962 NM_001145963 NM_001145964 NM_001253804 NM_009195 RefSeq (protein) NP_001139433 NP_001139434 NP_001139435 NP_001139436 NP_005063 NP_001240733 NP_033221 Location (UCSC) Chr 16: 67.94 – 67.97 Mb Chr 8: 106.67 – 106.69 Mb PubMed search [3] [4]
Wikidata
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See also

• Solute carrier family