Urea transporter 1

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.^[5][6]

SLC14A1
Identifiers
Aliases	SLC14A1, HUT11, HsT1341, JK, RACH1, RACH2, UT-B1, UT1, UTE, solute carrier family 14 member 1 (Kidd blood group), Jk(b), HUT11A, Jk(a)
External IDs	OMIM: 613868; MGI: 1351654; HomoloGene: 9285; GeneCards: SLC14A1; OMA:SLC14A1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 45,687,025 bp[1] End 45,752,520 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 78,143,306 bp[2] End 78,185,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia mucosa of urinary bladder trabecular bone right coronary artery internal globus pallidus ascending aorta dorsal motor nucleus of vagus nerve optic nerve substantia nigra prostate Top expressed in bone marrow urinary bladder male urethra ovary spleen inner renal medulla epithelium of male urethra female urethra renal vein Transitional epithelium of renal pelvis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function water transmembrane transporter activity urea channel activity urea transmembrane transporter activity protein binding Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane nucleolus intracellular membrane-bounded organelle membrane Biological process water transport urea transport urea transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6563 108052 Ensembl ENSG00000141469 ENSMUSG00000059336 UniProt Q13336 Q8VHL0 RefSeq (mRNA) NM_001128588 NM_001146036 NM_001146037 NM_001308278 NM_001308279 NM_015865 NM_001171010 NM_001171011 NM_028122 RefSeq (protein) NP_001122060 NP_001139508 NP_001139509 NP_001295207 NP_001295208 NP_056949 NP_001164481 NP_001164482 NP_082398 Location (UCSC) Chr 18: 45.69 – 45.75 Mb Chr 18: 78.14 – 78.19 Mb PubMed search [3] [4]
Wikidata
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Function

The SLC14A1 codes for a urea transporter (UTB) that is expressed in erythrocytes and kidney. SLC14A2 and SLC14A1 constitute solute carrier family 14. UTB proteins constitute the Kidd antigen system.