Monocarboxylate transporter 2

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.^[5] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid, branched-chain oxo acids derived from leucine, valine, and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.

SLC16A7
Identifiers
Aliases	SLC16A7, MCT2, solute carrier family 16 member 7
External IDs	OMIM: 603654; MGI: 1330284; HomoloGene: 20990; GeneCards: SLC16A7; OMA:SLC16A7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 59,596,029 bp[1] End 59,789,855 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 125,055,139 bp[2] End 125,225,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle renal medulla vena cava pericardium sperm cardia myocardium of left ventricle Skeletal muscle tissue of biceps brachii superior surface of tongue body of tongue Top expressed in spermatid seminiferous tubule spermatocyte seminal vesicula epithelium of stomach right kidney transitional epithelium of urinary bladder human kidney parotid gland hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function pyruvate transmembrane transporter activity symporter activity pyruvate secondary active transmembrane transporter activity lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process monocarboxylic acid transport lactate transmembrane transport pyruvate transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9194 20503 Ensembl ENSG00000118596 ENSMUSG00000020102 UniProt O60669 O70451 RefSeq (mRNA) NM_001270622 NM_001270623 NM_004731 NM_011391 NM_001358496 NM_001358915 RefSeq (protein) NP_001257551 NP_001257552 NP_004722 NP_035521 NP_001345425 NP_001345844 Location (UCSC) Chr 12: 59.6 – 59.79 Mb Chr 10: 125.06 – 125.23 Mb PubMed search [3] [4]
Wikidata
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Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.

Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.^[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.^[7]

See also

• Monocarboxylate transporter