Monocarboxylate transporter 3

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.^[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

SLC16A8
Identifiers
Aliases	SLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDs	OMIM: 610409; MGI: 1929519; HomoloGene: 75006; GeneCards: SLC16A8; OMA:SLC16A8 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,078,134 bp[1] End 38,084,184 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,135,214 bp[2] End 79,138,961 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium testicle nucleus accumbens sural nerve gonad C1 segment right uterine tube putamen Descending thoracic aorta ascending aorta Top expressed in retinal pigment epithelium choroid plexus of fourth ventricle Epithelium of choroid plexus gastrula embryo CA3 field ciliary body embryo saccule ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity Cellular component integral component of plasma membrane plasma membrane membrane integral component of membrane Biological process monocarboxylic acid transport pyruvate metabolic process leukocyte migration lactate transport transmembrane transport lactate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23539 57274 Ensembl ENSG00000100156 ENSMUSG00000032988 UniProt O95907 O35308 RefSeq (mRNA) NM_013356 NM_001394131 NM_020516 RefSeq (protein) NP_037488 NP_065262 Location (UCSC) Chr 22: 38.08 – 38.08 Mb Chr 15: 79.14 – 79.14 Mb PubMed search [3] [4]
Wikidata
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Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

• Monocarboxylate transporter