Excitatory amino acid transporter 4

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.^[5][6]

SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,950,033 bp[1] End 15,022,990 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 78,616,330 bp[2] End 78,650,599 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum endothelial cell left testis right testis paraflocculus of cerebellum skin of thigh cerebellar vermis nucleus accumbens oocyte caudate nucleus Top expressed in cerebellar vermis lobe of cerebellum dorsomedial hypothalamic nucleus lumbar subsegment of spinal cord ventromedial nucleus inferior colliculi superior colliculus dentate gyrus of hippocampal formation granule cell lateral hypothalamus ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function L-aspartate transmembrane transporter activity symporter activity L-glutamate transmembrane transporter activity amino acid transmembrane transporter activity high-affinity glutamate transmembrane transporter activity metal ion binding Cellular component integral component of membrane Golgi apparatus membrane intermediate filament cytoskeleton integral component of plasma membrane plasma membrane glutamatergic synapse integral component of presynaptic membrane Biological process chemical synaptic transmission regulation of membrane potential ion transport glutamate secretion aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate import across plasma membrane amino acid transport L-aspartate transmembrane transport neurotransmitter uptake transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6511 20513 Ensembl ENSG00000105143 ENSMUSG00000005357 UniProt P48664 O35544 RefSeq (mRNA) NM_001272087 NM_001272088 NM_005071 NM_001384669 NM_001384670 NM_001384671 NM_009200 RefSeq (protein) NP_001259016 NP_001259017 NP_005062 NP_033226 Location (UCSC) Chr 19: 14.95 – 15.02 Mb Chr 10: 78.62 – 78.65 Mb PubMed search [3] [4]
Wikidata
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EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.^[6]