Sodium/potassium/calcium exchanger 4

Sodium/potassium/calcium exchanger 4 also known as solute carrier family 24 member 4 is a protein that in humans is encoded by the SLC24A4 gene.^[4]

SLC24A4
Identifiers
Aliases	SLC24A4, AI2A5, NCKX4, SHEP6, SLC24A2, solute carrier family 24 member 4
External IDs	OMIM: 609840; MGI: 2447362; HomoloGene: 17798; GeneCards: SLC24A4; OMA:SLC24A4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 92,322,581 bp[1] End 92,501,481 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte primary visual cortex middle temporal gyrus sural nerve Brodmann area 23 blood granulocyte buccal mucosa cell gonad pons n/a More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity sodium ion binding calcium ion binding potassium ion binding symporter activity antiporter activity calcium, potassium:sodium antiporter activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane cytoplasm Biological process calcium ion transport sensory perception of smell sodium ion transport sodium ion transmembrane transport calcium ion transmembrane transport amelogenesis response to stimulus ion transport cellular calcium ion homeostasis potassium ion transport transmembrane transport potassium ion transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123041 238384 Ensembl ENSG00000140090 ENSMUSG00000041771 UniProt Q8NFF2 Q8CGQ8 RefSeq (mRNA) NM_153646 NM_153647 NM_153648 NM_001378620 NM_172152 NM_001362345 RefSeq (protein) NP_705932 NP_705933 NP_705934 NP_001365549 NP_742164 NP_001349274 Location (UCSC) Chr 14: 92.32 – 92.5 Mb n/a PubMed search [2] [3]
Wikidata
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Clinical effects

Mutations in SLC24A4 cause amelogenesis imperfecta.^[5][6][7]