Mitochondrial 2-oxoglutarate/malate carrier protein

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.^[5][6][7] Inactivating mutations in this gene predispose to metastasic paraganglioma.^[8]

SLC25A11
Identifiers
Aliases	SLC25A11, OGC, SLC20A4, solute carrier family 25 member 11, PGL6
External IDs	OMIM: 604165; MGI: 1915113; HomoloGene: 2637; GeneCards: SLC25A11; OMA:SLC25A11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,937,130 bp[1] End 4,940,053 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 43.21 cM Start 70,535,022 bp[2] End 70,538,305 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh right auricle of heart left ventricle gastrocnemius muscle body of tongue mucosa of transverse colon right frontal lobe prefrontal cortex Skeletal muscle tissue of rectus abdominis Top expressed in extraocular muscle right ventricle interventricular septum digastric muscle myocardium of ventricle plantaris muscle cardiac muscle tissue of left ventricle temporal muscle muscle of thigh sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding oxoglutarate:malate antiporter activity transmembrane transporter activity Cellular component integral component of membrane integral component of plasma membrane membrane mitochondrion nucleus mitochondrial inner membrane Biological process gluconeogenesis alpha-ketoglutarate transport mitochondrial transport transport transmembrane transport malate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8402 67863 Ensembl ENSG00000108528 ENSMUSG00000014606 UniProt Q02978 Q9CR62 RefSeq (mRNA) NM_003562 NM_001165417 NM_001165418 NM_024211 RefSeq (protein) NP_001158889 NP_001158890 NP_003553 NP_077173 Location (UCSC) Chr 17: 4.94 – 4.94 Mb Chr 11: 70.54 – 70.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family