Mitochondrial glycine transporter

Mitochondrial glycine transporter is a protein that in humans is encoded by the SLC25A38 gene. SLC25A38 is involved in mitochondrial handling of glycine and is needed for the first step in heme synthesis. Mutations in this gene can lead to an autosomal recessive form of sideroblastic anemia.

SLC25A38
Identifiers
Aliases	SLC25A38, SIDBA2, solute carrier family 25 member 38
External IDs	OMIM: 610819; MGI: 2384782; HomoloGene: 5553; GeneCards: SLC25A38; OMA:SLC25A38 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 39,383,370 bp[1] End 39,397,351 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 119,939,440 bp[2] End 119,953,570 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of thyroid gland left lobe of thyroid gland right lobe of liver rectum right uterine tube right adrenal cortex mucosa of transverse colon left adrenal gland left ovary Top expressed in fetal liver hematopoietic progenitor cell right kidney tibiofemoral joint granulocyte yolk sac zygote superior ganglion of glossopharyngeal nerve proximal tubule secondary oocyte muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function glycine transmembrane transporter activity transmembrane transporter activity Cellular component membrane mitochondrion mitochondrial inner membrane integral component of membrane Biological process heme biosynthetic process erythrocyte differentiation mitochondrial transport glycine import into mitochondrion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54977 208638 Ensembl ENSG00000144659 ENSMUSG00000032519 UniProt Q96DW6 Q91XD8 RefSeq (mRNA) NM_017875 NM_001354798 NM_144793 RefSeq (protein) NP_060345 NP_001341727 NP_659042 Location (UCSC) Chr 3: 39.38 – 39.4 Mb Chr 9: 119.94 – 119.95 Mb PubMed search [3] [4]
Wikidata
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