ADP/ATP translocase 1

ADP/ATP translocase 1, or adenine nucleotide translocator 1 (ANT1), is an enzyme that in humans is encoded by the SLC25A4 gene.^[5][6]

SLC25A4
Identifiers
Aliases	SLC25A4, AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1, PEOA2, solute carrier family 25 member 4, MTDPS12A
External IDs	OMIM: 103220; MGI: 1353495; HomoloGene: 36058; GeneCards: SLC25A4; OMA:SLC25A4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 185,143,266 bp[1] End 185,150,382 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B1.1|8 26.22 cM Start 46,659,834 bp[2] End 46,664,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle right ventricle apex of heart cardiac muscle tissue of right atrium body of tongue triceps brachii muscle vastus lateralis muscle thoracic diaphragm right auricle of heart Skeletal muscle tissue of rectus abdominis Top expressed in atrioventricular valve endocardial cushion atrium myocardium of ventricle cardiac muscles gastrocnemius muscle plantaris muscle extensor digitorum longus muscle interventricular septum right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding adenine transmembrane transporter activity ATP:ADP antiporter activity transmembrane transporter activity Cellular component integral component of membrane membrane myelin sheath integral component of plasma membrane mitochondrion nucleus mitochondrial inner membrane integral component of mitochondrial membrane Biological process mitochondrial genome maintenance regulation of insulin secretion negative regulation of necroptotic process generation of precursor metabolites and energy apoptotic mitochondrial changes transmembrane transport viral process adenine transport ATP transport regulation of mitochondrial membrane permeability ADP transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 291 11739 Ensembl ENSG00000151729 ENSMUSG00000031633 UniProt P12235 P48962 RefSeq (mRNA) NM_001151 NM_007450 RefSeq (protein) NP_001142 NP_031476 Location (UCSC) Chr 4: 185.14 – 185.15 Mb Chr 8: 46.66 – 46.66 Mb PubMed search [3] [4]
Wikidata
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Interactions

SLC25A4 has been shown to interact with Bcl-2-associated X protein.^[7]