Zinc transporter 1

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.^[5][6]

SLC30A1
Identifiers
Aliases	SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDs	OMIM: 609521; MGI: 1345281; HomoloGene: 6681; GeneCards: SLC30A1; OMA:SLC30A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 211,571,568 bp[1] End 211,579,161 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 97.01 cM Start 191,638,879 bp[2] End 191,645,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa caput epididymis Epithelium of choroid plexus skin of thigh trabecular bone dorsal motor nucleus of vagus nerve vulva cartilage tissue corpus epididymis human penis Top expressed in placenta lip ileum renal cortex proximal tubule human kidney primary oocyte hair secondary oocyte jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel inhibitor activity cation transmembrane transporter activity protein binding zinc ion transmembrane transporter activity Cellular component cytoplasm integral component of membrane Golgi apparatus nuclear membrane membrane T-tubule plasma membrane endoplasmic reticulum Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane Biological process negative regulation of neurotransmitter secretion calcium ion import zinc ion transport cellular calcium ion homeostasis response to zinc ion cation transport in utero embryonic development ion transport negative regulation of calcium ion import detoxification of cadmium ion negative regulation of zinc ion transmembrane import zinc ion transmembrane transport cellular zinc ion homeostasis cadmium ion transmembrane transport regulation of sequestering of zinc ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7779 22782 Ensembl ENSG00000170385 ENSMUSG00000037434 UniProt Q9Y6M5 Q60738 RefSeq (mRNA) NM_021194 NM_009579 RefSeq (protein) NP_067017 NP_033605 Location (UCSC) Chr 1: 211.57 – 211.58 Mb Chr 1: 191.64 – 191.65 Mb PubMed search [3] [4]
Wikidata
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Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation.^[7]

See also

• Solute carrier family