Sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.^[5][6][7]

SLC34A2
Identifiers
Aliases	SLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDs	OMIM: 604217; MGI: 1342284; HomoloGene: 2297; GeneCards: SLC34A2; OMA:SLC34A2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,648,011 bp[1] End 25,678,748 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 28.92 cM Start 53,195,423 bp[2] End 53,229,006 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung palpebral conjunctiva upper lobe of lung upper lobe of left lung bronchial epithelial cell right lung right uterine tube endometrium minor salivary glands right lobe of thyroid gland Top expressed in left lung left lung lobe right lung right lung lobe ileum jejunum spermatocyte spermatid corneal stroma morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphate ion binding sodium ion binding sodium:phosphate symporter activity symporter activity Cellular component integral component of membrane vesicle membrane plasma membrane integral component of plasma membrane brush border membrane apical plasma membrane brush border cytoplasm Biological process phosphate ion transport sodium-dependent phosphate transport sodium ion transport cellular phosphate ion homeostasis in utero embryonic development response to estrogen phosphate ion transmembrane transport sodium ion transmembrane transport ion transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10568 20531 Ensembl ENSG00000157765 ENSMUSG00000029188 UniProt O95436 Q9DBP0 RefSeq (mRNA) NM_006424 NM_001177998 NM_001177999 NM_011402 RefSeq (protein) NP_001171469 NP_001171470 NP_006415 NP_035532 Location (UCSC) Chr 4: 25.65 – 25.68 Mb Chr 5: 53.2 – 53.23 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.^[8]

As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.^[9]

See also

• Solute carrier family
• Pulmonary alveolar microlithiasis