Proton-coupled amino acid transporter 2

Proton-coupled amino acid transporter 2 is a protein which in humans is encoded by the SLC36A2 gene.^[5]

SLC36A2
Identifiers
Aliases	SLC36A2, PAT2, TRAMD1, solute carrier family 36 member 2
External IDs	OMIM: 608331; MGI: 1891430; HomoloGene: 72100; GeneCards: SLC36A2; OMA:SLC36A2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,314,972 bp[1] End 151,347,590 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 55,049,296 bp[2] End 55,075,903 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in quadriceps femoris muscle skeletal muscle tissue gastrocnemius muscle muscle of thigh human kidney tibial nerve testicle sural nerve gonad renal cortex Top expressed in brown adipose tissue sciatic nerve body of femur subcutaneous adipose tissue mammary gland intercostal muscle white adipose tissue humerus aorta otolith organ More reference expression data BioGPS n/a
Gene ontology Molecular function L-alanine transmembrane transporter activity amino acid:proton symporter activity L-proline transmembrane transporter activity glycine transmembrane transporter activity proton transmembrane transporter activity amino acid transmembrane transporter activity Cellular component cytoplasm integral component of membrane plasma membrane extracellular exosome membrane vacuolar membrane Biological process proline transmembrane transport ion transport amino acid transport glycine transport L-alanine transport proline transport proton transmembrane transport transport amino acid transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 153201 246049 Ensembl ENSG00000186335 ENSMUSG00000020264 UniProt Q495M3 Q8BHK3 RefSeq (mRNA) NM_181776 NM_153170 RefSeq (protein) NP_861441 NP_694810 Location (UCSC) Chr 5: 151.31 – 151.35 Mb Chr 11: 55.05 – 55.08 Mb PubMed search [3] [4]
Wikidata
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Function

SLC36A2 transports small amino acids (glycine, alanine, and proline) and also the D-enantiomers and select amino acid derivatives, such as gamma-aminobutyric acid.^[5][6]

Clinical significance

Mutations in the SLC36A2 gene are associated with Iminoglycinuria.^[7]

See also

• Proton coupled amino acid transporter