Putative sodium-coupled neutral amino acid transporter 10

Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10,^[5] is a protein that in humans is encoded by the SLC38A10 gene.^[6]

SLC38A10
Identifiers
Aliases	SLC38A10, PP1744, solute carrier family 38 member 10
External IDs	OMIM: 616525; MGI: 1919305; HomoloGene: 41556; GeneCards: SLC38A10; OMA:SLC38A10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,244,811 bp[1] End 81,295,547 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,994,786 bp[2] End 120,042,172 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary body of pancreas right lobe of liver right lobe of thyroid gland mucosa of transverse colon apex of heart right uterine tube right coronary artery left lobe of thyroid gland granulocyte Top expressed in motor neuron fossa calvaria aortic valve ascending aorta vestibular membrane of cochlear duct Paneth cell condyle external carotid artery iris More reference expression data BioGPS n/a
Gene ontology Molecular function amino acid transmembrane transporter activity Cellular component integral component of membrane membrane Golgi apparatus Biological process amino acid transmembrane transport bone development ion transport amino acid transport sodium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124565 72055 Ensembl ENSG00000157637 ENSMUSG00000061306 UniProt Q9HBR0 Q5I012 RefSeq (mRNA) NM_001037984 NM_138570 NM_001164798 NM_001164799 NM_001164800 NM_001164801 NM_001164802 NM_024249 NM_001361696 NM_001361697 NM_001361698 NM_001361699 RefSeq (protein) NP_001033073 NP_612637 NP_001158270 NP_001158271 NP_001158272 NP_001158273 NP_001158274 NP_077211 NP_001348625 NP_001348626 NP_001348627 NP_001348628 Location (UCSC) Chr 17: 81.24 – 81.3 Mb Chr 11: 119.99 – 120.04 Mb PubMed search [3] [4]
Wikidata
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Cellular localization

Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles.^[7]

Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.^[8]

Cancer

A SLC38A family member has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[9] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[9]