Sugar transporter SWEET1

Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene.^[5] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.^[6]

SLC50A1
Identifiers
Aliases	SLC50A1, HsSWEET1, RAG1AP1, SCP, SWEET1, slv, solute carrier family 50 member 1
External IDs	OMIM: 613683; MGI: 107417; HomoloGene: 40647; GeneCards: SLC50A1; OMA:SLC50A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,135,344 bp[1] End 155,138,857 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.04 cM Start 89,175,553 bp[2] End 89,177,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum body of pancreas right adrenal gland islet of Langerhans right adrenal cortex left adrenal gland right lobe of liver beta cell left adrenal cortex Top expressed in ankle joint primary visual cortex superior frontal gyrus Ileal epithelium lip islet of Langerhans carotid body epithelium of stomach right kidney parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function glucoside transmembrane transporter activity sugar transmembrane transporter activity Cellular component nucleus Golgi membrane membrane integral component of membrane Golgi apparatus endomembrane system plasma membrane Biological process carbohydrate transport epigenetic maintenance of chromatin in transcription-competent conformation glucoside transport hexose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55974 19729 Ensembl ENSG00000169241 ENSMUSG00000027953 UniProt Q9BRV3 Q9CXK4 RefSeq (mRNA) NM_001122837 NM_001122839 NM_001287586 NM_001287587 NM_001287588 NM_001287589 NM_001287590 NM_001287591 NM_001287592 NM_018845 NM_009057 RefSeq (protein) NP_001116309 NP_001116311 NP_001274515 NP_001274516 NP_001274517 NP_001274518 NP_001274519 NP_001274520 NP_001274521 NP_061333 NP_033083 Location (UCSC) Chr 1: 155.14 – 155.14 Mb Chr 3: 89.18 – 89.18 Mb PubMed search [3] [4]
Wikidata
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SWEET1 is a broadly-expressed glucose transporter.^[6] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.^[7] However, the bovine SLC50A1 homologue is associated with lactose concentration in milk,^[8] and the CiRGA homologue in the sea squirt Ciona intestinalis is essential for tissue differentiation during embryogenesis, especially the development of the notochord.^[9] SWEET genes are common in plant genomes, with around twenty paralogues ^[6] functioning as both sucrose and hexose transporters, and are also associated with pathogen susceptibility.^[6][10]