OSTbeta

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.^[5][6]

SLC51B
Identifiers
Aliases	SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2
External IDs	OMIM: 612085; MGI: 3582052; HomoloGene: 18721; GeneCards: SLC51B; OMA:SLC51B - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,045,387 bp[1] End 65,053,397 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,319,996 bp[2] End 65,330,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon duodenum rectum jejunal mucosa testicle mucosa of sigmoid colon popliteal artery tibial arteries right coronary artery Top expressed in jejunum ileum epithelium of small intestine right kidney proximal tubule duodenum human kidney Paneth cell large intestine colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein heterodimerization activity bile acid transmembrane transporter activity transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane basolateral plasma membrane protein-containing complex Biological process positive regulation of protein glycosylation regulation of protein stability positive regulation of protein exit from endoplasmic reticulum bile acid and bile salt transport positive regulation of protein targeting to membrane bile acid secretion transmembrane transport organic substance transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123264 330962 Ensembl ENSG00000186198 ENSMUSG00000053862 UniProt Q86UW2 Q80WK2 RefSeq (mRNA) NM_178859 NM_178933 RefSeq (protein) NP_849190 NP_849264 Location (UCSC) Chr 15: 65.05 – 65.05 Mb Chr 9: 65.32 – 65.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[7] The heterodimer furthermore is essential for intestinal bile acid transport.^[8]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[6]

See also

• OSTalpha
• OST Family
• Transporter Classification Database