Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.^[5]

SLCO1B3
Identifiers
Aliases	SLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDs	OMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.2 Start 20,810,702 bp[1] End 20,916,911 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G2|6 72.57 cM Start 141,575,244 bp[2] End 141,632,372 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle olfactory zone of nasal mucosa Epithelium of choroid plexus gonad nasal epithelium buccal mucosa cell tibial nerve canal of the cervix gallbladder Top expressed in left lobe of liver embryo sexually immature organism medial head of gastrocnemius muscle primary visual cortex proximal tubule jejunum thoracic diaphragm pancreas right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane basolateral plasma membrane integral component of plasma membrane membrane plasma membrane Biological process ion transport bile acid and bile salt transport organic anion transport sodium-independent organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28234 28253 Ensembl ENSG00000111700 ENSMUSG00000030236 UniProt Q9NPD5 Q9JJL3 RefSeq (mRNA) NM_019844 NM_001349920 NM_020495 NM_178235 RefSeq (protein) NP_062818 NP_001336849 NP_065241 Location (UCSC) Chr 12: 20.81 – 20.92 Mb Chr 6: 141.58 – 141.63 Mb PubMed search [3] [4]
Wikidata
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OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.^[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.^[7]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.^[7]

Substrates

Small molecules that are transported by SLCO1B3 include:^[8]

• Amanitin
• Atrasentan
• Bilirubin
• Bosentan
• BQ-123
• Bromsulphthalein (BSP)
• CDCA-NBD
• Cholate (CA)
• Cholecystokinin octapeptide (CCK-8)
• Dehydroepiandroserone-3-sulfate (DHEAS)
• Deltorphin II
• Demethylphalloin
• Digoxin
• Docetaxel
• [D-penicillamine2,5]enkephalin (DPDPE)
• Enalapril
• Estradiol-17β-glucuronide 5–25
• Estrone-3-sulfate
• Fexofenadine
• Fluvastatin
• Fluo-3
• Glutathione (GSH)
• Glycocholate (GCA)
• Glycoursodeoxycholate (GUDCA)
• Irinotecan
• Leukotriene C4 (LTC4)
• Methotrexate
• Microcystin
• Monoglyucuronosyl
• Olmesartan
• Ouabain
• Paclitaxel
• Phalloidin
• Pitavastatin
• Rifampicin
• Ro 48-5033 (Bosentan metabolite)
• Rosuvastatin
• SN-38
• Taurocholate (TCA)
• Taurochenodeoxycholate (TCDCA)
• Taurodeoxycholate (TDCA)
• Tauroursodeoxycholate (TUDCA)
• Telmisartan
• Thyroxine (T4)
• TR-14035
• Triiodothyronine (T3)
• Valsartan

See also

• Solute carrier family