Zinc finger FYVE domain-containing protein 9

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.^[5] SARA contains a double zinc finger (FYVE domain).

ZFYVE9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1DEV, 1MK2, 4BKW
Identifiers
Aliases	ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs	OMIM: 603755; MGI: 2652838; HomoloGene: 3527; GeneCards: ZFYVE9; OMA:ZFYVE9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 52,142,089 bp[1] End 52,348,671 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 108,494,663 bp[2] End 108,637,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon prefrontal cortex gastrocnemius muscle cerebellar cortex cerebellar hemisphere islet of Langerhans right hemisphere of cerebellum muscle of thigh internal globus pallidus testicle Top expressed in skeletal muscle tissue quadriceps femoris muscle cerebellar cortex muscle of thigh dentate gyrus of hippocampal formation granule cell primary visual cortex hippocampus proper superior frontal gyrus zone of skin Hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function 1-phosphatidylinositol binding serine-type peptidase activity protein binding metal ion binding protein domain specific binding Cellular component cytoplasm endosome early endosome early endosome membrane membrane cytosol intracellular membrane-bounded organelle protein-containing complex Biological process endocytosis transforming growth factor beta receptor signaling pathway proteolysis endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9372 230597 Ensembl ENSG00000157077 ENSMUSG00000034557 UniProt O95405 n/a RefSeq (mRNA) NM_004799 NM_007323 NM_007324 NM_183300 NM_001347163 NM_001384118 RefSeq (protein) NP_004790 NP_015563 n/a Location (UCSC) Chr 1: 52.14 – 52.35 Mb Chr 4: 108.49 – 108.64 Mb PubMed search [3] [4]
Wikidata
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SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.^[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.