SNC-80

SNC-80 is an opioid analgesic compound that selectively activates μ–δ opioid receptor heteromers^[1] and is used primarily in scientific research.^[2] Discovered in 1994, SNC-80 was a pioneering non-peptide compound regarded as a highly selective agonist for the δ-opioid receptor.^[3]

SNC-80

Clinical data
Other names	SNC-80
Identifiers
IUPAC name 4-[(R)-[(2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CAS Number	156727-74-1 N
PubChem CID	123924
IUPHAR/BPS	1611
ChemSpider	110453 Y
UNII	L842QB22SW
ChEBI	CHEBI:231727
ChEMBL	ChEMBL13470 Y
CompTox Dashboard (EPA)	DTXSID6045662
Chemical and physical data
Formula	C28H39N3O2
Molar mass	449.639 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N(CC)CC)c1ccc(cc1)[C@@H](N2C[C@H](N(C\C=C)C[C@@H]2C)C)c3cccc(OC)c3
InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1 Y Key:KQWVAUSXZDRQPZ-UMTXDNHDSA-N Y
NY (what is this?)  (verify)

SNC-80 was the first non-peptide compound developed that was regarded as a highly selective agonist for the δ-opioid receptor.^[4] It has been shown to produce useful analgesic,^[5] antidepressant^[6] and anxiolytic effects in animal studies,^[7][8] but its usefulness is limited by producing convulsions at high doses,^[9] and so SNC-80 is not used medically, although it is a useful compound in scientific research.