SPN1

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.^[5][6]

SNUPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XK5, 2P8Q, 2Q5D, 2QNA, 3GB8, 3GJX, 3LWW, 3NBY, 3NBZ, 3NC0
Identifiers
Aliases	SNUPN, KPNBL, RNUT1, Snurportin1, snurportin 1
External IDs	OMIM: 607902; MGI: 1913319; HomoloGene: 4166; GeneCards: SNUPN; OMA:SNUPN - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.2 Start 75,598,083 bp[1] End 75,626,469 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 56,858,162 bp[2] End 56,890,490 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis smooth muscle tissue skeletal muscle tissue muscle of thigh gonad gastrocnemius muscle right ovary left ovary fallopian tube Top expressed in otolith organ utricle primary oocyte zygote superior cervical ganglion hand morula interventricular septum secondary oocyte seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA cap binding RNA binding protein binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore nucleus intracellular anatomical structure Biological process snRNA import into nucleus protein import into nucleus spliceosomal snRNP assembly import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10073 66069 Ensembl ENSG00000169371 ENSMUSG00000055334 UniProt O95149 Q80W37 RefSeq (mRNA) NM_005701 NM_001042581 NM_001042588 NM_178374 RefSeq (protein) NP_001036046 NP_001036053 NP_005692 NP_848461 Location (UCSC) Chr 15: 75.6 – 75.63 Mb Chr 9: 56.86 – 56.89 Mb PubMed search [3] [4]
Wikidata
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The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5 is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.^[6]