Sperm-associated antigen 11B

Sperm-associated antigen 11B is a protein that in humans is encoded by the SPAG11B gene.^[5][6][7]

SPAG11B
Identifiers
Aliases	SPAG11B, EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11, sperm associated antigen 11B, SPAG11A
External IDs	OMIM: 606560; MGI: 3647173; HomoloGene: 83383; GeneCards: SPAG11B; OMA:SPAG11B - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 7,442,684 bp[1] End 7,463,674 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.3 Start 19,190,775 bp[2] End 19,193,026 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte endometrium left uterine tube cervix mucosa of esophagus ectocervix prefrontal cortex blood nucleus accumbens Top expressed in esophagus zone of skin ovary testicle thymus liver primary visual cortex spleen kidney muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component extracellular region Biological process spermatogenesis antimicrobial humoral immune response mediated by antimicrobial peptide defense response defense response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10407 546038 Ensembl ENSG00000164871 ENSG00000274405 ENSG00000288309 ENSMUSG00000059463 UniProt Q08648 Q6PDA7 Q8K4N2 Q3UW43 RefSeq (mRNA) NM_016512 NM_058200 NM_058201 NM_058202 NM_058203 NM_058206 NM_058207 NM_001034905 NM_001039563 NM_001286493 RefSeq (protein) NP_057596 NP_478107 NP_478108 NP_478109 NP_478110 NP_478113 NP_478114 NP_001075021 NP_001350655 NP_001075021 NP_001350655 NP_694755 NP_001030077 NP_001034652 NP_001273422 Location (UCSC) Chr 8: 7.44 – 7.46 Mb Chr 8: 19.19 – 19.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.^[7]