Sperm-associated antigen 9

C-jun-amino-terminal kinase-interacting protein 4 is a scaffold protein that in humans is encoded by the SPAG9 gene.^[5][6][7]

SPAG9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W83
Identifiers
Aliases	SPAG9, CT89, HLC-6, HLC4, JIP-4, JIP4, JLP, PHET, PIG6, HLC6, sperm associated antigen 9
External IDs	OMIM: 605430; MGI: 1918084; HomoloGene: 2954; GeneCards: SPAG9; OMA:SPAG9 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,962,174 bp[1] End 51,120,868 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 93,886,917 bp[2] End 94,016,911 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone sural nerve ganglionic eminence corpus callosum internal globus pallidus inferior ganglion of vagus nerve endothelial cell cartilage tissue subthalamic nucleus Top expressed in otolith organ utricle superior cervical ganglion sciatic nerve trigeminal ganglion substantia nigra mammillary body superior colliculus cerebellar vermis lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function JUN kinase binding MAP-kinase scaffold activity mitogen-activated protein kinase p38 binding protein binding kinesin binding signaling receptor complex adaptor activity Cellular component integral component of membrane microtubule organizing center acrosomal vesicle perinuclear region of cytoplasm extracellular exosome cytoplasmic vesicle cytoplasm cytosol lysosomal membrane Biological process positive regulation of muscle cell differentiation positive regulation of cell migration retrograde transport, endosome to Golgi positive regulation of neuron differentiation spermatogenesis negative regulation of protein homodimerization activity striated muscle cell differentiation protein homooligomerization positive regulation of MAPK cascade vesicle-mediated transport lysosome localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9043 70834 Ensembl ENSG00000008294 ENSMUSG00000020859 UniProt O60271 Q58A65 RefSeq (mRNA) NM_001130527 NM_001130528 NM_001251971 NM_003971 NM_172345 NM_001025428 NM_001025429 NM_001025430 NM_001199203 NM_001199204 NM_001199205 NM_027569 NM_001363157 RefSeq (protein) NP_001123999 NP_001124000 NP_001238900 NP_003962 NP_001020599 NP_001020600 NP_001020601 NP_001186132 NP_001186133 NP_001186134 NP_081845 NP_001350086 Location (UCSC) Chr 17: 50.96 – 51.12 Mb Chr 11: 93.89 – 94.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.^[7]

Clinical significance

SPAG9 is a potential biomarker for early cervical carcinoma^[8] bladder cancer,^[9] and lung cancer.^[10]

Interactions

SPAG9 has been shown to interact with MAX.^[11]