Sperm protein associated with the nucleus, X-linked, family member A1

Sperm protein associated with the nucleus on the X chromosome A is a protein that in humans is encoded by the SPANXA1 gene.^[3][4]

SPANXA1
Identifiers
Aliases	SPANXA1, CT11.1, NAP-X, SPAN-X, SPAN-Xa, SPAN-Xb, SPANX, SPANX-A, Sperm protein associated with the nucleus, X-linked, family member A1, CT11.3
External IDs	OMIM: 300305; HomoloGene: 88477; GeneCards: SPANXA1; OMA:SPANXA1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq27.2 Start 141,583,674 bp[1] End 141,585,011 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis gonad right coronary artery Descending thoracic aorta ascending aorta blood urinary system kidney n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30014 n/a Ensembl ENSG00000198021 n/a UniProt Q9NS26 n/a RefSeq (mRNA) NM_013453 n/a RefSeq (protein) NP_038481 n/a Location (UCSC) Chr X: 141.58 – 141.59 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

"Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa [sic] while attempting to further define its role in spermatogenesis."^[4]