Spondin 1

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.^[5] It is secreted by cells of the floor plate and may be involved in axon guidance^[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

SPON1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989; MGI: 2385287; HomoloGene: 4453; GeneCards: SPON1; OMA:SPON1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.2 Start 13,962,723 bp[1] End 14,268,133 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 113,365,235 bp[2] End 113,642,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder mucosa of sigmoid colon pericardium lower lobe of lung cardia mucosa of urinary bladder external globus pallidus right lung visceral pleura parietal pleura Top expressed in epithelium of lens iris ciliary body external carotid artery cervix internal carotid artery retinal pigment epithelium atrium decidua suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding extracellular matrix structural constituent LBD domain binding Cellular component extracellular matrix extracellular region endoplasmic reticulum lumen extracellular space collagen-containing extracellular matrix Biological process cell adhesion protein O-linked fucosylation positive regulation of protein processing positive regulation of protein binding negative regulation of amyloid-beta formation positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10418 233744 Ensembl ENSG00000262655 ENSMUSG00000038156 UniProt Q9HCB6 Q8VCC9 RefSeq (mRNA) NM_006108 NM_145584 RefSeq (protein) NP_006099 NP_663559 Location (UCSC) Chr 11: 13.96 – 14.27 Mb Chr 7: 113.37 – 113.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse