SR-17018

SR-17018
Identifiers
	IUPAC name 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one;
CAS Number	2134602-45-0 ;
PubChem CID	130431397;
ChemSpider	67886365;
UNII	2M8P7UAW4W;
ChEMBL	ChEMBL4452384;
PDB ligand	WH9 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID101336689 ;
Chemical and physical data
Formula	C19H18Cl3N3O
Molar mass	410.72 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCC1N2C3=CC(=C(C=C3NC2=O)Cl)Cl)CC4=CC=C(C=C4)Cl;
	InChI InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26); Key:LAGUDYUGRSQDKS-UHFFFAOYSA-N;

SR-17018 is a drug which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment.^[1] In animal studies it produces analgesic effects but with less respiratory depression and development of tolerance than conventional opioids.^[2]^[3]^[4]^[5] SR-17018 is also a noncompetitive opioid agonist.^[6] It produces very little hyperactivity in mice, does not induce locomotor sensitization and counteracts the hyperactivity produced by morphine.^[7]

Quick facts Identifiers, CAS Number ...

SR-17018 has been shown to reverse morphine tolerance and prevent withdrawal via a hitherto unknown mechanism of action.^[8]

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SR-17018

See also

References

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