SRG1 RNA

SRG1 RNA (SER3 regulatory gene 1) is a non-coding RNA which represses the expression of SER3 (YER081W).^[1][2][3] SER3 is a gene which codes for a phosphoglycerate dehydrogenase involved in the biosynthesis of serine.^[4] SRG1 represses SER3 expression via transcription interference, and in that respect is the first intergenic transcript of its kind.^[1]

SRG1
Conserved secondary structure of SRG1 RNA
Identifiers
Symbol	SRG1
Rfam	RF01765
Other data
RNA type	Gene; Cis-reg;
Domain(s)	Saccharomyces
PDB structures	PDBe

SRG1 was identified when chromatin immunoprecipitation (ChIP) assays showed that in Saccharomyces cerevisiae, even when SER3 was being repressed, TATA-binding protein and RNA Polymerase II were still bound to the SER3 DNA in such a way that should have caused active transcription.^[1] Further analysis found a second TATA box 558 bp upstream of SER3. A bioinformatic scan identified this same TATA box element in related Saccharomyces.^[5] SRG1 has been found to be cis-acting, it had no repressive effect when in trans.^[1]

SRG1 RNA is unrelated to Senescence Related Gene 1 (SRG1), a protein-coding gene found in Arabidopsis thaliana,^[6] and is also distinct from Stress Response Gene 1 (SRG1) found in Medicago sativa.^[7][8]