Serglycin

Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.^[5] It is primarily expressed in hematopoietic cells and endothelial cells,^[6] and is the only known intracellular proteoglycan.^[7]

SRGN
Identifiers
Aliases	SRGN, PPG, PRG, PRG1, serglycin
External IDs	OMIM: 177040; MGI: 97756; HomoloGene: 2043; GeneCards: SRGN; OMA:SRGN - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 69,088,103 bp[1] End 69,104,805 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 62,329,612 bp[2] End 62,363,230 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow monocyte bone marrow cell blood appendix periodontal fiber pericardium endothelial cell granulocyte Top expressed in gastrula decidua granulocyte blood tibiofemoral joint right lung lobe dermis bone marrow cervix spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi apparatus extracellular region platelet alpha granule lumen extracellular space mast cell granule Schaffer collateral - CA1 synapse glutamatergic synapse postsynaptic specialization, intracellular component Biological process negative regulation of bone mineralization biomineral tissue development platelet degranulation protease localization to mast cell secretory granule granzyme-mediated apoptotic signaling pathway apoptotic process protein processing mast cell secretory granule organization T cell secretory granule organization maintenance of protease location in mast cell secretory granule maintenance of granzyme B location in T cell secretory granule modulation of chemical synaptic transmission regulation of postsynapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5552 19073 Ensembl ENSG00000122862 ENSMUSG00000020077 UniProt P10124 P13609 RefSeq (mRNA) NM_002727 NM_001321053 NM_001321054 NM_011157 NM_001358965 RefSeq (protein) NP_001307982 NP_001307983 NP_002718 NP_035287 NP_001345894 Location (UCSC) Chr 10: 69.09 – 69.1 Mb Chr 10: 62.33 – 62.36 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis.^[5][8]