St6 beta-galactoside alpha-2,6-sialyltransferase 2

ST6 beta-galactoside alpha-2,6-sialyltransferase 2 is a protein that in humans is encoded by the ST6GAL2 gene.^[4]

ST6GAL2
Identifiers
Aliases	ST6GAL2, SIAT2, ST6GalII, ST6 beta-galactoside alpha-2,6-sialyltransferase 2
External IDs	OMIM: 608472; MGI: 2445190; HomoloGene: 13052; GeneCards: ST6GAL2; OMA:ST6GAL2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 106,801,600 bp[1] End 106,887,108 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery ganglionic eminence Descending thoracic aorta ascending aorta left coronary artery germinal epithelium thyroid gland gonad right lobe of thyroid gland left lobe of thyroid gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity catalytic activity sialyltransferase activity glycosyltransferase activity beta-galactoside alpha-2,6-sialyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus membrane Golgi membrane Biological process multicellular organism development protein glycosylation oligosaccharide metabolic process sialylation protein N-linked glycosylation via asparagine growth carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84620 240119 Ensembl ENSG00000144057 ENSMUSG00000024172 UniProt Q96JF0 Q76K27 RefSeq (mRNA) NM_001142351 NM_001142352 NM_032528 NM_001322362 NM_172829 RefSeq (protein) NP_001135823 NP_001135824 NP_001309291 NP_115917 NP_001334332 Location (UCSC) Chr 2: 106.8 – 106.89 Mb n/a PubMed search [2] [3]
Wikidata
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Function

This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].