SUI1

Single-domain protein From Wikipedia, the free encyclopedia

SUI1

In molecular biology, the single-domain protein SUI1 is a translation initiation factor often found in the fungus, Saccharomyces cerevisiae (Baker's yeast) but it is also found in other eukaryotes and prokaryotes as well as archaea. It is otherwise known as Eukaryotic translation initiation factor 1 (eIF1) in eukaryotes or YciH in bacteria.[1]

Quick Facts Identifiers, Symbol ...
SUI1
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NMR solution structure of E. coli yciH gene.
Identifiers
SymbolSUI1
PfamPF01253
InterProIPR001950
PROSITEPDOC00862
SCOP22if1 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
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Function

SUI1 is a translation initiation factor that directs the ribosome to the translation start site, helped by eIF2 and the initiator Met-tRNAiMet.[2] SUI1 ensures that translation initiation commences from the correct start codon (usually AUG), by stabilizing the pre-initiation complex around the start codon. SUI1 promotes a high initiation fidelity for the AUG codon, discriminating against non-AUG codons.[3]

In E. coli however, it seems that the SUI1 homolog YciH is an inhibitor of translation during stress instead.[4]

Structure

The primary structure of the SUI1 protein is made up of 108 amino acids. The protein domain has a structure made of a seven-bladed beta-propeller and it also contains a C-terminal alpha helix.[5] Homologues of SUI1 have been found [6] in mammals, insects and plants. SUI1 is also evolutionary related to proteins from Escherichia coli (yciH), Haemophilus influenzae (HI1225) and Methanococcus vannielii.[5]

References

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