Salcaprozate sodium

Salcaprozate sodium (SNAC) is an intestinal permeation enhancer that is used in drug formulations particularly for macromolecules and poorly permeable compounds.^[1][2] SNAC has been used in formulations of drugs that have undergone clinical trials and has achieved generally recognized as safe (GRAS) status, with U.S. Food and Drug Administration approval for use in a medical food products.^[1][2]

Salcaprozate sodium

Identifiers
IUPAC name sodium;8-[(2-hydroxybenzoyl)amino]octanoate
CAS Number	203787-91-1
PubChem CID	23669833
ChemSpider	139678
UNII	1YTW0422YU
KEGG	D05787
ChEMBL	ChEMBL2107027
CompTox Dashboard (EPA)	DTXSID50174306
Chemical and physical data
Formula	C15H20NNaO4
Molar mass	301.318 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+]
InChI InChI=InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1 Key:UOENJXXSKABLJL-UHFFFAOYSA-M

An oral formulation of semaglutide that includes SNAC has been approved for use human use in the United States and Europe.^[3]