Salsalate

Salsalate is a medication that belongs to the salicylate and nonsteroidal anti-inflammatory drug (NSAID) classes.

Salsalate

Clinical data
Trade names	Disalcid, Salflex
AHFS/Drugs.com	Monograph
MedlinePlus	a682880
ATC code	N02BA06 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name 2-(2-Hydroxybenzoyl)oxybenzoic acid
CAS Number	552-94-3 Y
PubChem CID	5161
DrugBank	DB01399 Y
ChemSpider	4977 N
UNII	V9MO595C9I
KEGG	D00428 N
ChEBI	CHEBI:9014 N
CompTox Dashboard (EPA)	DTXSID1023572
ECHA InfoCard	100.008.208
Chemical and physical data
Formula	C14H10O5
Molar mass	258.229 g·mol−1
NY (what is this?)  (verify)

Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.^[1]

Mechanism of action

Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several proinflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein.^[2]

The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased action of NF-κB genes.^[2][3][4] This mechanism is thought to be responsible for salsalate's insulin-sensitizing and blood sugar lowering properties.^[3]

Medical uses

Salsalate may be used for inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.^[2][5]

Safety

The risk of bleeding is a common concern with use of the NSAID class of medications. However, the bleeding risk associated with salsalate is lower than that associated with aspirin use.^[3]

Research

Salsalate has been proposed for the prevention and treatment of type 2 diabetes mellitus due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes.^[2] However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.^[2]

History

Salsalate had been suggested as possible treatment for diabetes as early as 1876.^[2][6][7]

Synthesis

Salsalate synthesis:^{[8][9][10][11]}