Sameridine

Sameridine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).

Sameridine

Clinical data
ATC code	none
Identifiers
IUPAC name N-ethyl-1-hexyl-N-methyl-4-phenylpiperidine-4-carboxamide
CAS Number	143257-97-0
PubChem CID	65996
ChemSpider	59388 Y
UNII	NQP2Y50Y6B
ChEMBL	ChEMBL2104504
CompTox Dashboard (EPA)	DTXSID30162367
Chemical and physical data
Formula	C21H34N2O
Molar mass	330.516 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N(CC)C)C2(c1ccccc1)CCN(CCCCCC)CC2
InChI InChI=1S/C21H34N2O/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3 Y Key:TYWUGCGYWNSRPS-UHFFFAOYSA-N Y
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Sameridine has an unusual pharmacological profile, being both a local anaesthetic and a μ-opioid partial agonist.^[1] It is currently under development for use in surgical anasthesia, mainly administered by intrathecal infusion.^[2] It produces less respiratory depression than morphine, even at a high dose, and produces no respiratory depression at a low dose.^[3]

Sameridine is not currently a controlled drug, although if approved for medical use it will certainly be a prescription medicine, and it would probably be assigned to one of the controlled drug schedules in more restrictive jurisdictions such as Australia and the United States, especially if it were found to be addictive in animals.