Sarcophagine

Sarcophagine (Sar) is a bicyclic cage-like metal chelator molecule^[1] derived from cyclam. Chemical formula of sarcophagine is 3,6,10,13,16,19-hexaazabicyclo(6,6,6)icosane^[2] and additional functional groups are often linked to this structure, such as in DiAmSar (1,8-diamino-Sar). This and many related hexadentate clathrochelates are prepared by template reactions.^[3]

Chemical structure of DiAmSar

Sarcophagine

Names
Preferred IUPAC name 3,6,10,13,16,19-Hexazabicyclo[6.6.6]icosane
Other names Sar chelate
Identifiers
CAS Number	64189-50-0 Y[ChemSpider]
3D model (JSmol)	Interactive image
ChemSpider	4908238
PubChem CID	6394006
CompTox Dashboard (EPA)	DTXSID30214390
InChI InChI=1S/C14H32N6/c1-2-16-8-14-11-19-5-3-17-9-13(7-15-1)10-18-4-6-20-12-14/h13-20H,1-12H2 Key: NVOVSXGZALWAFS-UHFFFAOYSA-N
SMILES C1CNCC2CNCCNCC(CN1)CNCCNC2
Properties
Chemical formula	C14H32N6
Molar mass	284.452 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Sarcophagine derivatives are used, for example, as ligands in radiopharmaceuticals that require incorporating a radioactive metal cation into an organic and/or biological structure, such as an antibody.^[4]