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Scianna antigen system
From Wikipedia, the free encyclopedia
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The Scianna blood antigen system consists of seven antigens.[1][2] These include two high frequency antigens Sc1 and Sc3, and two low frequency antigens Sc2 and Sc4.[1]
The very rare null phenotype is characterised by the absence of Sc1, Sc2 and Sc3.[1]
The antigens are caused by changes in the erythroid membrane associated protein (ERMAP).[3][4]
History
This blood group system was discovered in 1962 when a high frequency antigen was detected in a young woman (Ms. Scianna) who had experienced several late pregnancy losses due to haemolytic disease of the fetus.[3]
References
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