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Second Genome
From Wikipedia, the free encyclopedia
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Second Genome is a venture capital funded, life sciences research company based in South San Francisco.[1] The company's focus is on the development and exploitation of a research platform which facilitates the identification and elucidation of relationships between human physiology and the human microbiota,[1][2] and it has a long term goal of becoming a drug development company.[3] The name "second genome" comes from the notion that humans have, effectively, two genomes: the native human genome, and the more diverse set of genomes carried by the human microbiota.[4]
The company's first foray into drug development was a small molecule treatment for ulcerative colitis (SGM-1019).[3][5][notes 1][notes 2] The mechanism of SGM-1019 has not been disclosed in detail.[5] Key to the company's business model has been partnerships with large established pharmaceutical companies, including Pfizer and Janssen.[1] Potential competitors to Second Genome include Kaleido Biosciences, Synlogic, Kallyope, Seres Therapeutics, OpenBiome, Rebiotix, Evelo Therapeutics,[2] and Vedanta Biosciences.[3]
Second Genome was founded in 2010 by Corey Goodman, a venture capitalist and former Pfizer executive,[3] and Todd DeSantis, the company's vice president for informatics as of 2019.[6] As of 2013, the company had entered into an ulcerative colitis research agreement with Janssen,[7] the financial arrangement and outcome of which remains to be determined. The company had a headcount of 18 employees as of 2014,[update][1] which had increased to 25 by 2016.[3] Startup financing was obtained through a Series A round which raised US$11.5 million.[1] A Series B round of funding raised US$42.6 million in 2016.[3] By 2016, the company had established a DNA sequencing service aimed at microbial samples, which provided revenue to supplement venture capital infusions.[3] As of 2019, the company had secured a two-year SBIR grant in collaboration with Oregon State University, aimed at studying microbiome metabolites from people with nervous system disorders, in particular autism.[6]
As of 2016[update], the company's president and chief executive officer was Peter DiLaura.[1][3]
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