Securinine

Securinine is an alkaloid found in Securinega suffruticosa^[1] and Phyllanthus niruri.^[2]

Securinine

Identifiers
IUPAC name (1S,2R,8S)-14-Oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
CAS Number	5610-40-2
PubChem CID	442872
ChemSpider	391181
UNII	G4VS580P5E
KEGG	C10614
ChEBI	CHEBI:9079
ChEMBL	ChEMBL303062
CompTox Dashboard (EPA)	DTXSID7045944
ECHA InfoCard	100.222.962
Chemical and physical data
Formula	C13H15NO2
Molar mass	217.268 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
InChI InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1 Key:SWZMSZQQJRKFBP-WZRBSPASSA-N

Pharmacology

Securinine has pro-convulsant effects^[3][4] and it has a strong spastic effect, similar to the actions of strychnine.^[5]

Securinine is a GABA-_A antagonist.^[6][7]

See also

• Norsecurinine
• Phenazine