Selective receptor modulator

In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.^[1] An SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.

Selective receptor modulator
Drug class
Tamoxifen, a SERMTooltip selective estrogen receptor modulator and a widely used drug in the treatment of breast cancer.
Class identifiers
Synonyms	SRM
Use	Various
Biological target	Steroid hormone receptor
Chemical class	Steroidal; Nonsteroidal
Legal status
In Wikidata

Classes

Classes of selective receptor modulators include:

• Selective androgen receptor modulator (SARM)
• Selective estrogen receptor modulator (SERM)
• Selective glucocorticoid receptor modulator (SEGRM)
• Selective progesterone receptor modulator (SPRM)
• Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα)

See also

• Agonist–antagonist
• Selective glucocorticoid receptor agonist (SEGRA)