Setastine

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.^[1][2]

Setastine

Identifiers
IUPAC name 1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane
CAS Number	64294-95-7 HCl: 59767-13-4 Y
PubChem CID	43082
ChemSpider	39258
UNII	6G3OCF528J HCl: T2MB6P84ON Y
CompTox Dashboard (EPA)	DTXSID30867067
Chemical and physical data
Formula	C22H28ClNO
Molar mass	357.92 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN3CCCCCC3

Pharmacology

Pharmacodynamics

Setastine acts as a highly selective H₁ receptor antagonist.^[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics

Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.^[3]

See also

• Clemastine