Setogepram

Setogepram
Clinical data
Other names	PBI-4050, Fezagepras
Identifiers
	IUPAC name 2-(3-pentylphenyl)acetic acid;
CAS Number	1002101-19-0;
PubChem CID	24749700;
IUPHAR/BPS	10043;
DrugBank	DB15447;
ChemSpider	58107628;
UNII	879OVM0Y1S;
ChEMBL	ChEMBL4297635;
Chemical and physical data
Formula	C13H18O2
Molar mass	206.285 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCC1=CC(=CC=C1)CC(=O)O;
	InChI InChI=1S/C13H18O2/c1-2-3-4-6-11-7-5-8-12(9-11)10-13(14)15/h5,7-9H,2-4,6,10H2,1H3,(H,14,15); Key:PEGQOIGYZLJMIB-UHFFFAOYSA-N;

Setogepram (PBI-4050, Fezagepras) is an experimental drug which acts as a mixed agonist-antagonist for certain free fatty acid receptors, being an agonist at FFAR1 (GPR40) but an antagonist at GPR84. It has antiinflammatory and anti-fibrotic effects and has reached Phase II human clinical trials for treatment of idiopathic pulmonary fibrosis.^[1]^[2]^[3]^[4]^[5]

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References