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Sinus tubercle

Proliferation of endoderm induced by the paramesonephric ducts From Wikipedia, the free encyclopedia

Sinus tubercle
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Sinus tubercle (also known as sinual tubercle[1] or Müllerian eminence) is the proliferation of endoderm induced by the paramesonephric ducts. It is located in the developing fetus between the orifices of the mesonephric ducts on the urogenital sinus.[1] The uterovaginal primoridium, which is a fusion of the caudal ends of paramesonephric ducts, contacts the dorsal wall of the urogenital sinus and, induces the formation of the sinus tubercle. This occurs in both sexes:

  • In the female, the mesonephric duct loses all association with the gonad and disappears. The sinus tubercle then gives rise to the sino-vaginal bulbs and, when it later becomes solid it is referred to as the vaginal plate.[1] It likewise gives rise to the hymen, which eventually breaks down in most cases.
  • In the males, the sinus tubercle gives rise to the seminal colliculus.
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