Sivelestat

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.^[1]

Sivelestat

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	None
Legal status
Legal status	US: Not approved In general: ℞ (Prescription only)
Identifiers
IUPAC name N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
CAS Number	127373-66-4 N
PubChem CID	107706
IUPHAR/BPS	6441
ChemSpider	96875 Y
UNII	DWI62G0P59
KEGG	D03788 Y
ChEMBL	ChEMBL76688 Y
CompTox Dashboard (EPA)	DTXSID9048304
Chemical and physical data
Formula	C20H22N2O7S
Molar mass	434.46 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) Y Key:BTGNGJJLZOIYID-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

It is used in the treatment of acute respiratory failure^[2] and preliminary studies show it may also improve neuropathic pain.^[3]

Synthesis

Sivelestat is synthesised as follows:^[4]