Small nucleolar RNA SNORA69

In molecular biology, Small nucleolar RNA SNORA69 (also known as U69) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

Small nucleolar RNA SNORA69
Predicted secondary structure and sequence conservation of SNORA69
Identifiers
Symbol	SNORA69
Alt. Symbols	U69
Rfam	RF00265
Other data
RNA type	Gene; snRNA; snoRNA; H/ACA-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000594
PDB structures	PDBe

ACA69 was originally cloned from HeLa cells^[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA69 is predicted to guide the pseudouridylation of U36 of 18S and U69 of 5.8S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.